Rat Lung Aldose Reductase Inhibition Capacity of Substituted Indole Hydrazide/Hydrazone Derivatives
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چکیده
Diabetes mellitus is a chronic metabolic disorder, and diabetic complications lead to morbidity and death in diabetic patients. Hyperglycemia has been shown to be the most important risk factor in charge for the systemic complications. Various biochemical pathways have been proposed to explain the adverse effects of hyperglycemia. Potential cellular mechanisms of hyperglycemia-induced complications are the activation of diacylglycerol-protein kinase C, increased polyol pathway, enhanced reactive oxygen species production, nonenzymatic glycation and advanced glycation end products pathway (1-4).
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تاریخ انتشار 2015